Naomi's charity work also includes ongoing projects with Nelson Mandela Children's Fund, Fashion for Relief™, Breakthrough Breast Cancer, Quincy Jones' Listen Up Foundation and Fidel Castro's Cuban Children's Fund. Naomi has a very special and deep friendship with Nelson Mandela who she works with side-by-side on his charity work.

Quincy Jones is also an extremely close friend, part of her family and an inspirational element in her life. She continues to support his breakthrough Listen Up Foundation, which merges the power of Hollywood to help champion youth causes. Additionally, she was the first celebrity to appear in the Fashion Targets Breast Cancer campaign in 1996.

Naomi was named the international ambassador of Rio De Janeiro by the city's Mayor Cesar Maia. At a meeting in 2006, Naomi and the Mayor agreed to work on various projects for her charity We Love Brazil, which she founded for the children of Brazil.